It's important when you are looking to finance a new home that you don't obligate yourself to more than you can afford. If you choose a loan/payment amount too high your house will end up owning you..instead of the other way around. However, if you choose a loan too low, you'll lose some tax benefits and the equity you will build in future years.
Only you can determine the loan amount that's best for your individual needs. You might want to start with 4 times your annual salary and then adjust from there. Online mortgage calculators are also a great resource to help you with the analysis.